(rac)-AG-205 [442656-02-2]

MedChem Express

(rac)-AG-205 [442656-02-2]

10

442656-02-2

Research Use Only

C22H23ClN6OS

454.98

(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1].

CC1=CC2=C(C=C1)N(C3C2CN(CC3)C)C(CSC4=NN=NN4C5=CC=C(C=C5)Cl)=O

12352200