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ProductsBack/Rad50 antibody [13B3]

Rad50 antibody [13B3]

GTX70228
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Monkey, Mouse, Rat
TargetRAD50
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Overview

  • Supplier
    GeneTex
  • Product Name
    Rad50 antibody [13B3] - KO/KD, Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    13B3
  • Concentration
    1.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10111
  • Target name
    RAD50
  • Target description
    RAD50 double strand break repair protein
  • Target synonyms
    DNA repair protein RAD50; hRad50; NBSLD; RAD50 homolog, double strand break repair protein; RAD502
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ92878
  • Protein Name
    DNA repair protein RAD50
  • Scientific Description
    The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
  • Reactivity
    Human, Monkey, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC.
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  • Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection.
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  • Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase.
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  • Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair.
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  • Cisplatin-induced cell death increases the degradation of the MRE11-RAD50-NBS1 complex through the autophagy/lysosomal pathway.
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  • Novel viral splicing events and open reading frames revealed by long-read direct RNA sequencing of adenovirus transcripts.
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  • Increased Resection at DSBs in G(2)-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Xiao H et al., 2022 Jul 2, Cells
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  • A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. Boddin J et al., 2022 Apr 26, mBio
    Read more
  • Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA. Price AM et al., 2022 Feb 22, Nucleic Acids Res
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  • RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma. Ko JMY et al., 2021 Sep 21, Cancers (Basel)
    Read more