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RapaLink-1

HY-111373
MedChem Express
CAS Number1887095-82-0
DownloadMSDS
Product group Chemicals
Estimated Purity99.27
Molecular Weight1784.14
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Overview

  • Supplier
    MedChem Express
  • Product Name
    RapaLink-1 [1887095-82-0]
  • Delivery Days Customer
    9
  • CAS Number
    1887095-82-0
  • Certification
    Research Use Only
  • Estimated Purity
    99.27
  • Molecular Formula
    C91H138N12O24
  • Molecular Weight
    1784.14
  • Scientific Description
    RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin (HY-10219) with MLN0128 (HY-13328, a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity [1] [2] .
  • SMILES
    NC1=C(C2=NC=N1)C(C3=CC=C(O4)C(N=C4N)=C3)=NN2CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCN(N=N5)C=C5COCCO[C@H](CC[C@H]6C[C@H]([C@@](CC([C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H]7C)C)=O)OC)O)\C)C)=O)([H])OC([C@@](CCCC8)([H])N8C(C([C@@]9(O[C@@](C[C@@H](/C(C)=C/C=C/C=C/7)OC)([H])CC[C@H]9C)O)=O)=O)=O)C)[C@@H](C6)OC)=O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200