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RapaLink-1

M28992
AbMole BioScience
CAS Number1887095-82-0
Product group Chemicals
Molecular Weight1784.14
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    RapaLink-1
  • Delivery Days Customer
    9
  • CAS Number
    1887095-82-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C91H138N12O24
  • Molecular Weight
    1784.14
  • Scientific Description
    RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity.
  • Storage Instruction
    4°C, dry, sealed
  • UNSPSC
    12352200

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