RAS inhibitor Abd-7

MedChem Express

RAS inhibitor Abd-7 [2351843-48-4]

10

2351843-48-4

Research Use Only

99.16

C23H25N3O3

391.46

RAS inhibitor Abd-7, a potent RAS-binding compound ( K d =51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V [1] .

COC1=NC(C2=C3C(OCCO3)=CC=C2)=CC=C1NC4=CC=C(CN(C)C)C=C4

-20°C,2°C to 8°C

12352200