RAS inhibitor Abd-7 [2351843-48-4]

TargetMol Chemicals

RAS inhibitor Abd-7 [2351843-48-4]

14

2351843-48-4

Research Use Only

RAS inhibitor Abd-7

C23H25N3O3

391.46

RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].

3 years

COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12

-20°C

51202000