RASD2 antibody

GeneTex

RASD2 antibody - KO/KD Validated

9

WB: 1:500. IP: 1:100. ELISA: 1:10000. IHC: 1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

RASD2

RASD family member 2

GTP-binding protein Rhes; Ras homolog enriched in striatum; Rhes; TEM2; tumor endothelial marker 2

Rabbit

IgG

GTP-binding protein Rhes

This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]

-20°C or -80°C,2°C to 8°C

12352203