Western blot analysis of extracts of various cell lines using RASSF1 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using RASSF1 Polyclonal Antibody at 1:1000 dilution.
RASSF1 Polyclonal Antibody
E-AB-60249
Product group Antibodies
Overview
- SupplierElabscience
- Product NameRASSF1 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
- UNSPSC12352203