Recombinant Human IL-7

Biorbyt

Recombinant Human IL-7

10

Application Notes: For research use only. Minimum Sample Size: 50microg/vial

Research Use Only

≥95%

Interleukin-7

Interleukin (IL)-7 is a 25 kDa secreted soluble globular protein produced by cells, such as fetal liver cells, stromal cells in the bone marrow (BM), and thymus and other epithelial cells, including keratinocytes and enterocytes. Its receptor (IL-7R) is a heterodimeric complex consisting of IL-7Ralpha and the common gamma chain, shared with the receptors for IL-2, -4, -7, -9, -15 and -21. IL-7Ralpha is expressed in early thymocytes, T cells, pre-B cells, BM macrophages, and other immune cells. In these cells, IL-7-mediated signaling initiates downstream signaling pathways through JAK1/3, and PI3K, which further leads to the activation and phosphorylation of STATs. Src family kinases are also activated by IL-7 binding. These kinases play an important role in developing B cells, but their function in IL-7 signaling has not been fully elucidated. IL-7 contributes to host defense by regulating the development and homeostasis of immune cells, including T lymphocytes, B lymphocytes, and natural killer (NK) cells.

CHO Cell - Human

-20°C or -80°C,2°C to 8°C

12352202