Regorafenib

MedChem Express

Regorafenib [755037-03-7]

10

755037-03-7

99.93

C21H15ClF4N4O3

482.82

Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC 50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3 , PDGFRbeta , Kit , RET and Raf-1 , respectively. Regorafenib shows very robust antitumor and antiangiogenic activity [1] .

O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F

-20°C,2°C to 8°C

12352200