Resatorvid

MedChem Express

Resatorvid [243984-11-4]

10

243984-11-4

Research Use Only

99.95

C15H17ClFNO4S

361.82

Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-alpha and IL-6 production with IC 50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases [1] [2] .

O=S([C@H]1C(C(OCC)=O)=CCCC1)(NC2=CC=C(C=C2Cl)F)=O

-20°C,2°C to 8°C

12352200