RGB-286638 [784210-87-3]

MedChem Express

RGB-286638 [784210-87-3]

10

784210-87-3

Research Use Only

99.70

C29H37Cl2N7O4

618.55

RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3beta, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.

O=C(NN1CCOCC1)NC2=CC=CC(C3=C4C(C5=CC=C(CN6CCN(CCOC)CC6)C=C5)=NN3)=C2C4=O.[H]Cl.[H]Cl

2°C to 8°C

12352200