Rigosertib

MedChem Express

Rigosertib [592542-59-1]

10

592542-59-1

Research Use Only

99.01

C21H25NO8S

451.49

Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle [1] [2] . Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC 50 of 9 nM [3] .

COC1=CC=C(C=C1NCC(O)=O)CS(/C=C/C2=C(C=C(C=C2OC)OC)OC)(=O)=O

-20°C

12352200