RING1 Antibody

Cusabio

RING1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

RING1

ring finger protein 1

E3 ubiquitin-protein ligase RING1; polycomb complex protein RING1; really interesting new gene 1 protein; RING1A; RING-type E3 ubiquitin transferase RING1; RNF1

Rabbit

IgG

E3 ubiquitin-protein ligase RING1

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of Lys-119 of histone H2A, thereby playing a central role in histone code and gene regulation. H2A Lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. Cao R., Tsukada Y., Zhang Y.Mol. Cell 20:845-854(2005) Satijn D.P.E., Gunster M.J., van der Vlag J., Hamer K.M. Mol. Cell. Biol. 17:4105-4113(1997)

Human, Mouse, Rat

-20°C or -80°C

41116161