RNF111 Polyclonal Antibody

Reddot Biotech

RNF111 Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.84 mg/ml

Unconjugated

RNF111

ring finger protein 111

ARK; Arkadia; E3 ubiquitin-protein ligase Arkadia; hRNF111; RING-type E3 ubiquitin transferase Arkadia

Rabbit

IgG

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Human

-20°C

12352203