RNF144B antibody [11F4]

GeneTex

RNF144B antibody [11F4]

9

WB: 1:1000-1:2000. ICC/IF: 1:50-1:100. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

11F4

0.8 mg/ml

Unconjugated

RNF144B

ring finger protein 144B

IBRDC2, PIR2, bA528A10.3, p53RFP, E3 ubiquitin-protein ligase RNF144B, IBR domain containing 2, IBR domain-containing protein 2, p53-inducible RING finger protein

Mouse

IgG1

E3 ubiquitin-protein ligase RNF144B

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death - But, it is not an anti-apoptotic protein per se.

-20°C or -80°C,2°C to 8°C

12352203