Ro 46-8443 [175556-12-4]

MedChem Express

Ro 46-8443 [175556-12-4]

10

175556-12-4

Research Use Only

98.93

C31H35N3O8S

609.69

Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM)[1][2].

O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC(C3=CC=C(OC)C=C3)=NC(OC[C@H](O)CO)=C2OC4=CC=CC=C4OC)=O

2°C to 8°C

12352200