RO5454948 [1386979-55-0]

MedChem Express

RO5454948 [1386979-55-0]

10

1386979-55-0

Research Use Only

99.53

C23H17Cl2N5O4

498.32

RO5454948 (Compound 9) is the inhibitor for Dyrk1B and Dyrk1A with IC50 of 68 nM and 22 nM. RO5454948 exhibits cytotoxicity in cancer cell SW620 with EC50 of 1.9 microM[1][2].

ClC1=CC=C(C(NCC2=CC(Cl)=CC=C2)=O)C=C1NC(C3=CC4=CN=C(OC)N=C4N=C3O)=O

-20°C,2°C to 8°C

12352200