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Rolapitant (hydrochloride) [858102-79-1]

HY-14751A
MedChem Express
CAS Number858102-79-1
Product group Chemicals
Molecular Weight536.94
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Rolapitant (hydrochloride) [858102-79-1]
  • Delivery Days Customer
    10
  • CAS Number
    858102-79-1
  • Certification
    Research Use Only
  • Molecular Formula
    C25H27ClF6N2O2
  • Molecular Weight
    536.94
  • Scientific Description
    Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model[1][2].
  • SMILES
    O=C1N[C@]2(CN[C@@](C3=CC=CC=C3)(CO[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C)CC2)CC1.[H]Cl
  • UNSPSC
    12131703