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RTICBM-189

ORB1146626
Biorbyt
CAS Number551909-15-0
Product group Chemicals
Molecular Weight309.19
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Overview

  • Supplier
    Biorbyt
  • Product Name
    RTICBM-189 [551909-15-0]
  • Delivery Days Customer
    10
  • CAS Number
    551909-15-0
  • Certification
    Research Use Only
  • Molecular Formula
    C15H14Cl2N2O
  • Molecular Weight
    309.19
  • Scientific Description
    RTICBM-189 is a Urea derivative and a CB1 allosteric modulator. RTICBM-189 showed no activity at > 50 protein targets and excellent brain permeation but relatively low metabolic stability in rat liver microsomes. Pharmacokinetic studies in rats confirmed the excellent brain exposure of 31 with a brain/plasma ratio Kp of 2.0. Importantly, intraperitoneal administration of RTICBM-189 significantly and selectively attenuated the reinstatement of the cocaine-seeking behavior in rats without affecting locomotion.
  • SMILES
    O=C(NCCC1=CC=CC(Cl)=C1)NC2=CC=C(Cl)C=C2
  • UNSPSC
    12352200

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