Western blot analysis of extracts of various cell lines using RUNX2 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of various cell lines using RUNX2 Polyclonal Antibody at dilution of 1:1000.
RUNX2 Polyclonal Antibody
E-AB-62026
Product group Antibodies
Overview
- SupplierElabscience
- Product NameRUNX2 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
- UNSPSC12352203