Samuraciclib

MedChem Express

Samuraciclib [1805833-75-3]

10

1805833-75-3

Research Use Only

C22H30N6O

394.51

Samuraciclib (CT7001) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC 50 of 41 nM. Samuraciclib displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC 50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib inhibits the growth of breast cancer cell lines with GI 50 values between 0.2-0.3 microM. Samuraciclib has anti-tumor effects [1] [2] .

O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=CC=CC=C4)=C2

12352200