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Chemical Structure
Chemical Structure
Chemical Structure

SAR-020106 [1184843-57-9]

Research Use Only
SYN-1189
SYNkinase
CAS Number1184843-57-9
Product group Chemicals
Estimated Purity>95%
Molecular Weight382.9
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Overview

  • Supplier
    SYNkinase
  • Product Name
    SAR-020106 [1184843-57-9]
  • Delivery Days Customer
    10
  • CAS Number
    1184843-57-9
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C19H19ClN6O
  • Molecular Weight
    382.9
  • Scientific Description
    Chemical. CAS: 1184843-57-9. Formula: C19H19ClN6O. MW: 382.9. SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo. - SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3nM on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55nM in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    51202000