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SAR-020106

M11418
AbMole BioScience
CAS Number1184843-57-9
Product group Chemicals
Molecular Weight382.85
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    SAR-020106
  • Delivery Days Customer
    9
  • CAS Number
    1184843-57-9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C19H19ClN6O
  • Molecular Weight
    382.85
  • Scientific Description
    Sar-020106 is an ATP-competitive and selective CHK1 inhibitor with an IC50 of 13.3 nM. Sar-020106 has good selectivity to CHK2. Sar-020106 increased cell lethality of Gemcitabine and SN38 by 3.0 to 29 times in a p53-dependent manner in several colon cancer cell lines. Sar-020106 can enhance antitumor activity by selecting anticancer drugs.
  • SMILES
    CC(CN(C)C)OC1=C(N=CC(=N1)NC2=NC=C3C(=CC=CC3=C2)Cl)C#N
  • UNSPSC
    12352200

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Chemical Structure
Product group Chemicals
SYNkinase
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Estimated Purity>95%
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SAR-020106 [1184843-57-9]
Product group Chemicals
TargetMol Chemicals
SAR-020106 [1184843-57-9]T21331
CAS Number1184843-57-9
Estimated Purity0.9778
Molecular Weight382.85
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