SAR405

MedChem Express

SAR405 [1523406-39-4]

10

1523406-39-4

Research Use Only

99.74

C19H21ClF3N5O2

443.85

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor ( IC 50 =1.2 nM; K d =1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity [1] [2] .

O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4

-20°C,2°C to 8°C

12352200