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SAR405 [1523406-39-4]

SAR405 [1523406-39-4]

T12831L
TargetMol Chemicals
CAS Number1523406-39-4
Product group Chemicals
Estimated Purity99.79%
Molecular Weight443.85
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SAR405 [1523406-39-4]
  • Delivery Days Customer
    9
  • CAS Number
    1523406-39-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    SAR405
  • Estimated Purity
    99.79%
  • Molecular Formula
    C19H21ClF3N5O2
  • Molecular Weight
    443.85
  • Scientific Description
    SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.
  • Shelf life instruction
    3 years
  • SMILES
    C[C@@H]1COCCN1c1cc(=O)n2CC[C@H](N(Cc3cncc(Cl)c3)c2n1)C(F)(F)F
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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