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SB-277011 dihydrochloride

SB-277011 dihydrochloride

T12861L
TargetMol Chemicals
CAS Number1226917-67-4
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Product group Chemicals
Molecular Weight511.49
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SB-277011 dihydrochloride
  • Delivery Days Customer
    65
  • CAS Number
    1226917-67-4
  • Category Supplier
    Chemical
  • Chemical Name
    SB-277011 dihydrochloride
  • Molecular Formula
    C28H32Cl2N4O
  • Molecular Weight
    511.49
  • Scientific Description
    SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
  • Shelf life instruction
    3 years
  • SMILES
    N#CC1=CC=C(C(CC2)=C1)CN2CC[C@@H](CC3)CC[C@H]3NC(C4=CC=NC5=C4C=CC=C5)=O.Cl.Cl
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Stemp G, et al. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat. J Med Chem. 2000 May 4;43(9):1878-85.
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