SB-277011 (hydrochloride)

MedChem Express

SB-277011 (hydrochloride) [215804-67-4]

9

215804-67-4

Research Use Only

98.54

C28H31ClN4O

475.02

SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate? dopamine D 3 ?receptor (D 3 R) ?antagonist with K i values of 10.7?nM and?11.2 nM?at?rodent and human?D 3 R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with? pK i s of 8.0, 6.0, 1B , and 5-HT 1D receptors, respectively [1] [2] .

O=C(C1=CC=NC2=CC=CC=C21)N[C@@H]3CC[C@H](CC3)CCN4CC5=C(CC4)C=C(C#N)C=C5.[H]Cl

2°C to 8°C

12352200