SB-657510

MedChem Express

SB-657510 [474960-44-6]

10

474960-44-6

Research Use Only

99.84

C19H22BrClN2O5S

505.81

SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The K i values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells [1] [2] .

ClC(C=C1)=C(O[C@H]2CN(C)CC2)C=C1NS(C3=CC(OC)=C(OC)C=C3Br)(=O)=O

-20°C,2°C to 8°C

12352200