SC75741 [913822-46-5]

MedChem Express

SC75741 [913822-46-5]

10

913822-46-5

Research Use Only

99.51

C29H23N7O2S2

565.67

SC75741 is a broad and efficient NF-kappaB inhibitor with an IC50 of 200 nM for p65[1]. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-kappaB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins[2].

O=C(NC1=NC(C=CC(C(C2=CC=CC=C2)=O)=C3)=C3N1)C4=CSC(C(CC5)CCN5C6=NC=NC7=C6SC=C7)=N4

-20°C,2°C to 8°C

12352200