SC75741

AbMole BioScience

SC75741

9

913822-46-5

Chemical

Research Use Only

>99%

C29H23N7O2S2

565.67

SC75741 is a broad and potent INHIBITOR of NF-kappaB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-kappaB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins.

O=C(NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CC=C3)C4=CSC(=N4)C5CCN(CC5)C6=C7SC=CC7=NC=N6

12352200