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SDHB antibody

GTX113833
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSDHB
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Overview

  • Supplier
    GeneTex
  • Product Name
    SDHB antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.42 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID6390
  • Target name
    SDHB
  • Target description
    succinate dehydrogenase complex iron sulfur subunit B
  • Target synonyms
    CWS2; IP; iron-sulfur subunit of complex II; MC2DN4; PGL4; SDH; SDH1; SDH2; SDHIP; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP21912
  • Protein Name
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • Scientific Description
    Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury.
    Read more
  • Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. Zhao M et al., 2022 Apr 1, Nat Commun
    Read more
  • The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress. Lee H et al., 2020 May 8, J Biol Chem
    Read more
  • The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II. Min HY et al., 2019 Oct 24, Cell Death Dis
    Read more
  • Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntingtons disease. Siew JJ et al., 2019 Aug 2, Nat Commun
    Read more
  • Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the alpha-Ketoglutarate Signaling Pathway. Tseng CW et al., 2018 Jun 1, Cancer Res
    Read more
  • IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy. Ishiyama A et al., 2017 Oct, Neurol Genet
    Read more
  • The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure. Lee H et al., 2017 Apr 28, J Biol Chem
    Read more