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Senicapoc [289656-45-7]

Senicapoc [289656-45-7]

T3528
TargetMol Chemicals
CAS Number289656-45-7
DownloadMSDS
Product group Chemicals
Estimated Purity99.50%
Molecular Weight323.34
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Senicapoc [289656-45-7]
  • Delivery Days Customer
    4
  • CAS Number
    289656-45-7
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Senicapoc
  • Estimated Purity
    99.50%
  • Molecular Formula
    C20H15F2NO
  • Molecular Weight
    323.34
  • Scientific Description
    Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 +/- 2 nM (CLT IC50 = 100 +/- 12 nM) and inhibits RBC dehydration with an IC50 of 30 +/- 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.
  • Shelf life instruction
    3 years
  • SMILES
    NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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