WB analysis of 5C6 cell lysate using GTX16170 Separase antibody [XJ11-1B12]. Lane 1: non-induced lysate Lane 2 : lysate induced with ponasterone
WB analysis of 5C6 cell lysate using GTX16170 Separase antibody [XJ11-1B12]. Lane 1: non-induced lysate Lane 2 : lysate induced with ponasterone
Separase antibody [XJ11-1B12]
GTX16170
Overview
- SupplierGeneTex
- Product NameSeparase antibody [XJ11-1B12]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDXJ11-1B12
- Concentration0.9 mg/ml
- ConjugateUnconjugated
- Gene ID9700
- Target nameESPL1
- Target descriptionextra spindle pole bodies like 1, separase
- Target synonymscaspase-like protein ESPL1; ESP1; extra spindle pole bodies 1, separase; extra spindle pole bodies homolog 1; extra spindle poles like 1; extra spindle poles-like 1 protein; SEPA; separin; separin, cysteine protease
- HostMouse
- IsotypeIgG1
- Protein IDQ14674
- Protein NameSeparin
- Scientific DescriptionStable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM]
- ReactivityHuman, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203