Separase antibody [XJ11-4D7]

GeneTex

Separase antibody [XJ11-4D7]

9

ICC/IF: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoCytoChemistry

Research Use Only

Monoclonal

XJ11-4D7

Unconjugated

ESPL1

extra spindle pole bodies like 1, separase

ESP1, SEPA, separin, caspase-like protein ESPL1, extra spindle pole bodies 1, separase, extra spindle pole bodies homolog 1, extra spindle poles like 1, extra spindle poles-like 1 protein, separin, cysteine protease

Mouse

IgG2a

Separin

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM]

-20°C or -80°C,2°C to 8°C

12352203