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SETDB1 antibody [N1], N-term

Research Use Only
GTX115305
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetSETDB1
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Overview

  • Supplier
    GeneTex
  • Product Name
    SETDB1 antibody [N1], N-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.53 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID9869
  • Target name
    SETDB1
  • Target description
    SET domain bifurcated histone lysine methyltransferase 1
  • Target synonyms
    ERG-associated protein with a SET domain, ESET; ESET; H3-K9-HMTase4; histone H3-K9 methyltransferase 4; histone-lysine N-methyltransferase SETDB1; histone-lysine N-methyltransferase, H3lysine-9 specific 4; KG1T; KMT1E; lysine N-methyltransferase 1E; SET domain bifurcated 1; TDRD21; tudor domain containing 21
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ15047
  • Protein Name
    Histone-lysine N-methyltransferase SETDB1
  • Scientific Description
    This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. Wu K et al., 2020 Jan 7, Cell Rep
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  • Significance of histone methyltransferase SETDB1 expression in colon adenocarcinoma. Ho YJ et al., 2017 Nov, APMIS
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  • H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Chen J et al., 2013 Jan, Nat Genet
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