Immunohistochemistry of paraffin-embedded Human brain tissue using SGK1 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human brain tissue using SGK1 Monoclonal Antibody at dilution of 1:200.
SGK1 Monoclonal Antibody
E-AB-22207
Product group Antibodies
Overview
- SupplierElabscience
- Product NameSGK1 Monoclonal Antibody
- Delivery Days Customer12
- Scientific DescriptionProtein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
- UNSPSC12352203