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ProductsBack/SHC1 Polyclonal Antibody

Immunohistochemistry of paraffin-embedded Rat kidney using SHC1 Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded Rat kidney using SHC1 Polyclonal Antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded Rat kidney using SHC1 Polyclonal Antibody at dilution of 1:100 (40x lens).

SHC1 Polyclonal Antibody

E-AB-62212

Product group Antibodies

Overview

Supplier
Elabscience
Product Name
SHC1 Polyclonal Antibody
Delivery Days Customer
12
Certification
Research Use Only
Scientific Description
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
UNSPSC
12352203