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SHIN1 [2146095-85-2]

Research Use Only
T12897L
TargetMol Chemicals
CAS Number2146095-85-2
DownloadMSDS
Product group Chemicals
Molecular Weight400.47
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SHIN1 [2146095-85-2]
  • Delivery Days Customer
    4
  • CAS Number
    2146095-85-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    SHIN1
  • Molecular Formula
    C24H24N4O2
  • Molecular Weight
    400.47
  • Scientific Description
    SHIN1 (RZ-2994) is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
  • Shelf life instruction
    3 years
  • SMILES
    CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.
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