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Simvastatin (MK 733)

M3497
AbMole BioScience
CAS Number79902-63-9
DownloadDatasheet
Product group Chemicals
Estimated Purity0.9941
Molecular Weight418.57
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Simvastatin (MK 733)
  • Delivery Days Customer
    9
  • CAS Number
    79902-63-9
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Estimated Purity
    0.9941
  • Molecular Formula
    C25H38O5
  • Molecular Weight
    418.57
  • Scientific Description
    Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment.
  • SMILES
    CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12
  • UNSPSC
    12352200