Siramesine [147817-50-3]
HY-14221
CAS Number147817-50-3
Product group Chemicals
Molecular Weight454.58
Overview
- SupplierMedChem Express
- Product NameSiramesine [147817-50-3]
- Delivery Days Customer10
- CAS Number147817-50-3
- CertificationResearch Use Only
- Molecular FormulaC30H31FN2O
- Molecular Weight454.58
- Scientific DescriptionSiramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17?nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
- SMILESFC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1
- UNSPSC12352200