SKA2 antibody

GeneTex

SKA2 antibody

9

WB: 0.5 - 1 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SKA2

spindle and kinetochore associated complex subunit 2

FAM33A; family with sequence similarity 33, member A; spindle and kinetochore-associated protein 2; spindle and KT (kinetochore) associated 2

Rabbit

IgG

Spindle and kinetochore-associated protein 2

Upon entry into mitosis, the cells microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs. A recently discovered spindle and kinetochore complex, comprised of proteins SKA1, SKA2, and SKA3, has been found to be required for stable KT-MT interactions and timely anaphase onset. Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT, but does not impact overall KT structure. Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state, indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing. SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation.

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203