IHC-P analysis of human kidney tissue using GTX85522 SKI antibody. Working concentration : 20 microg/ml
IHC-P analysis of human kidney tissue using GTX85522 SKI antibody. Working concentration : 20 microg/ml
SKI antibody
GTX85522
Overview
- SupplierGeneTex
- Product NameSKI antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1 - 2 microg/mL. IHC-P: 20 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- FormulationLiquid
- Gene ID6497
- Target nameSKI
- Target descriptionSKI proto-oncogene
- Target synonymsproto-oncogene c-Ski; SGS; ski oncogene; ski oncoprotein; SKV; v-ski avian sarcoma viral oncogene homolog
- Protein IDP12755
- Protein NameSki oncogene
- Scientific DescriptionTGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203