ICC/IF analysis of SLC31A1 / CTR1 overexpressing cells with (left) or without (right) peptide competition using GTX48534 SLC31A1 / CTR1 antibody.
ICC/IF analysis of SLC31A1 / CTR1 overexpressing cells with (left) or without (right) peptide competition using GTX48534 SLC31A1 / CTR1 antibody.
SLC31A1 / CTR1 antibody
GTX48534
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Porcine, Rat, Xenopus, Zebra Fish
TargetSLC31A1
Overview
- SupplierGeneTex
- Product NameSLC31A1 / CTR1 antibody
- Delivery Days Customer9
- Application Supplier NoteICC/IF: 1:500. IHC-P: 1:250. IHC: 1:250. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID1317
- Target nameSLC31A1
- Target descriptionsolute carrier family 31 member 1
- Target synonymscopper transport 1 homolog; copper transporter 1; COPT1; CTR1; high affinity copper uptake protein 1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1
- HostRabbit
- IsotypeIgG
- Protein IDO15431
- Protein NameHigh affinity copper uptake protein 1
- Scientific DescriptionCopper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated. The 2 related genes ATP7A (MIM 300011) and ATP7B (MIM 606882), responsible for the human diseases Menkes syndrome (MIM 309400) and Wilson disease (MIM 277900), respectively, are involved in copper export. In S. cerevisiae, the copper uptake genes CTR1, CTR2, and CTR3 have been identified, and in human the CTR1 and CTR2 (MIM 603088) genes have been identified.[supplied by OMIM]
- ReactivityHuman, Mouse, Porcine, Rat, Xenopus, Zebra Fish
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma. Ryumon S et al., 2019 Dec, Oncol RepRead more
- Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy. Tsimberidou AM et al., 2015, Clin EpigeneticsRead more
- Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) in preclinical models of cancer. Valtorta S et al., 2013 Jul, J Nucl MedRead more