SLFN11 Antibody, FITC conjugated

Cusabio

SLFN11 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

SLFN11

schlafen family member 11

SLFN8/9, schlafen family member 11

Rabbit

IgG

Schlafen family member 11

Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.

Human

-20°C or -80°C

41116161