SN-38

MedChem Express

SN-38 [86639-52-3]

10

86639-52-3

Research Use Only

99.89

C22H20N2O5

392.40

SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 microM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5] .

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(O)=CC=C5N=C4C3=C2)=O

-20°C,2°C to 8°C

12352200