Sorafenib

MedChem Express

Sorafenib [284461-73-0]

10

284461-73-0

Research Use Only

99.92

C21H16ClF3N4O3

464.83

Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC 50 s of 6 nM and 20 nM for Raf-1 and B-Raf , respectively. Sorafenib is a multikinase inhibitor with IC 50 s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2 , VEGFR3 , PDGFRbeta , FLT3 and c-Kit , respectively. Sorafenib induces autophagy and apoptosis . Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator [1] .

O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3

-20°C,2°C to 8°C

12352200