SORL1 Antibody

Cusabio

SORL1 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

SORL1

sortilin related receptor 1

C11orf32; gp250; LDLR relative with 11 ligand-binding repeats; low-density lipoprotein receptor relative with 11 ligand-binding repeats; LR11; LRP9; mosaic protein LR11; SORLA; SorLA-1; sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; sorting protein-related receptor containing LDLR class A repeats

Rabbit

IgG

Sortilin-related receptor

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

-20°C or -80°C

12352203