The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA194090(SORT1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA194090(SORT1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
SORT1 Antibody
CSB-PA194090
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSORT1
Overview
- SupplierCusabio
- Product NameSORT1 Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID6272
- Target nameSORT1
- Target descriptionsortilin 1
- Target synonyms100 kDa NT receptor; glycoprotein 95; Gp95; LDLCQ6; neurotensin receptor 3; NT3; NTR3; sortilin
- HostRabbit
- IsotypeIgG
- Protein IDQ99523
- Protein NameSortilin
- Scientific DescriptionThis gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C
- UNSPSC41116161
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![Binding of Progranulin (human) (rec.) (untagged) (Prod. No. AG-40A-0188Y) to Sortilin (human) (rec.) (His) (Prod. No. AG-40B-0229) is inhibited by the antibody Sortilin (human), mAb (rec.) (blocking) [Latozinemab Bioimilar] (Prod. No. AG-27B-7000PF). Methods: Progranulin (human) (rec.) (untagged) is coated on an ELISA plate at 1 microg/ml. Sortilin (human), mAb (rec.) (blocking) [Latozinemab Biosimilar] or an unrelated mAb (Control) is added (starting at 20 microg/ml with a twofold serial dilution) together with 250 ng/ml of Sortilin (rec.) (His) for 1 hour. The binding is detected using an anti-His (HRP) incubated for 30 minutes followed by addition of the substrate TMB. The decreasing ODs observed in the Y axis represent the binding between Progranulin and Sortilin that is inhibited in a dose-dependent manner by Sortilin (human), mAb (rec.) (blocking) [Latozinemab Biosimilar]. This inhibition is not observed with the control antibody.](https://adipogen.com/pub/media/catalog/product/a/g/ag-27b-7000pf-binding_blocking_assay-500px.jpg)
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