SOX2 (Embryonic Stem Cell Marker)(rSOX2/1792), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

SOX2 (Embryonic Stem Cell Marker)(rSOX2/1792), CF594 conjugate, 0.1mg/mL

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

rSOX2/1792

0.1 mg/ml

Other Conjugate

SOX2

SRY-box transcription factor 2

ANOP3; MCOPS3; sex determining region Y-box 2; SRY (sex determining region Y)-box 2; SRY-box 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2

Mouse

IgG1

Transcription factor SOX-2

SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

2°C to 8°C

12352203